The second cast, which is where most of a long run actually happens and almost none of the credit goes. Helen Gallagher followed Gwen Verdon into Sweet Charity and won a Tony for it. Laurie Beechman followed Betty Buckley into Cats and played it for four years. Matched on the biography, so one or two of these takeovers happened somewhere other than a Broadway stage.
12 in the catalogue.
| Helen Gallagher | 1926–2024 | 16 productions |
| Betty Bruce | 1920–1974 | 5 productions |
| George Lee Andrews | 1942 | 4 productions |
| Jane Summerhays | 1944 | 4 productions |
| Jason Alexander | 1959 | 3 productions |
| Laurie Beechman | 1953–1998 | 3 productions |
| Savannah Wise | 1984 | 3 productions |
| Edmund Lyndeck | 1925–2015 | 2 productions |
| Jack Klugman | 1922–2012 | 2 productions |
| Jessie Matthews | 1907–1981 | 1 productions |
| Mimi Hines | 1933–2024 | 1 productions |
| Tom Powers | 1890–1955 | 1 productions |